Ageing affects dual encoding of periodicity and envelope shape in rat inferior colliculus neurons.

ABSTRACT: Extracting temporal periodicities and envelope shapes of sounds is important for listening within complex auditory scenes but declines behaviorally with age. Here, we recorded local field potentials (LFPs) and spikes to investigate how ageing affects the neural representations of different modulation rates and envelope shapes in the inferior colliculus of rats. We specifically aimed to explore the input-output (LFP-spike) response transformations of inferior colliculus neurons. Our results show that envelope shapes up to 256-Hz modulation rates are represented in the neural synchronisation phase lags in younger and older animals. Critically, ageing was associated with (i) an enhanced gain in onset response magnitude from LFPs to spikes; (ii) an enhanced gain in neural synchronisation stren

SUBMITTER: Herrmann B 

PROVIDER: S-EPMC5247336 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature