Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine.

ABSTRACT:

Background & aims

The transcription factor atonal homolog 1 (ATOH1) controls the fate of intestinal progenitors downstream of the Notch signaling pathway. Intestinal progenitors that escape Notch activation express high levels of ATOH1 and commit to a secretory lineage fate, implicating ATOH1 as a gatekeeper for differentiation of intestinal epithelial cells. Although some transcription factors downstream of ATOH1, such as SPDEF, have been identified to specify differentiation and maturation of specific cell types, the bona fide transcriptional targets of ATOH1 still largely are unknown. Here, we aimed to identify ATOH1 targets and to identify transcription factors that are likely to co-regulate gene expression with ATOH1.

Methods

We used a combination of chromatin immunopre

SUBMITTER: Lo YH 

PROVIDER: S-EPMC5247424 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature