Visceral hyperalgesia caused by peptide YY deletion and Y2 receptor antagonism.

ABSTRACT: Altered levels of colonic peptide YY (PYY) have been reported in patients suffering from functional and inflammatory bowel disorders. While the involvement of neuropeptide Y (NPY) and Y receptors in the regulation of nociception is well established, the physiological role of PYY in somatic and visceral pain is poorly understood. In this work, the role of PYY in pain sensitivity was evaluated using PYY knockout (PYY^(-/-)) mice and Y2 receptor ligands. PYY^(-/-) mice were more sensitive to somatic thermal pain compared to wild type (WT) mice. Visceral pain was assessed by evaluating pain-related behaviors, mouse grimace scale (MGS) and referred hyperalgesia after intrarectal administration of allyl isothiocyanate (AITC, 1 or 2%) or its vehicle, peanut oil. The pain-relat

SUBMITTER: Hassan AM 

PROVIDER: S-EPMC5247702 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature