Modeling Stem Cell Myogenic Differentiation.

ABSTRACT: The process of stem cell myogenesis (transformation into skeletal muscle cells) includes several stages characterized by the expression of certain combinations of myogenic factors. The first part of this process is accompanied by cell division, while the second part is mainly associated with direct differentiation. The mechanical cues are known to enhance stem cell myogenesis, and the paper focuses on the stem cell differentiation under the condition of externally applied strain. The process of stem cell myogenic differentiation is interpreted as the interplay among transcription factors, targeted proteins and strain-generated signaling molecule, and it is described by a kinetic multi-stage model. The model parameters are optimally adjusted by using the available data from the experiment w

SUBMITTER: Deshpande RS 

PROVIDER: S-EPMC5247743 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature