Tracking the origin of simultaneous endometrial and ovarian cancer by next-generation sequencing - a case report.

ABSTRACT:

Background

Endometrioid adenocarcinoma of the uterus and ovarian endometrioid carcinoma share many morphological and molecular features. Differentiation between simultaneous primary carcinomas and ovarian metastases of an endometrial cancer may be very challenging but is essential for prognostic and therapeutic considerations.

Case presentation

In the present case study of a 33 year-old patient we used targeted amplicon next-generation re-sequencing for clarifying the origin of synchronous endometrioid cancer of the corpus uteri and the left ovary. The patient developed a metachronous lung metastasis of an endometrioid adenocarcinoma four years after hyster- and adnexectomy, vaginal brachytherapy and treatment with the synthetic steroid tibolone. Removal of the metastasis an

SUBMITTER: Valtcheva N 

PROVIDER: S-EPMC5247816 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature