The respiratory microbiome in bronchial mucosa and secretions from severe IgE-mediated asthma patients.

ABSTRACT:

Background

The bronchial microbiome in chronic lung diseases presents an abnormal pattern, but its microbial composition and regional differences in severe asthma have not been sufficiently addressed. The aim of the study was to describe the bacterial community in bronchial mucosa and secretions of patients with severe chronic asthma chronically treated with corticosteroids in addition to usual care according to Global Initiative for Asthma. Bacterial community composition was obtained by 16S rRNA gene amplification and sequencing, and functional capabilities through PICRUSt.

Results

Thirteen patients with severe asthma were included and provided 11 bronchial biopsies (BB) and 12 bronchial aspirates (BA) suitable for sequence analyses. Bacteroidetes, Firmicutes, Proteobacter

SUBMITTER: Millares L 

PROVIDER: S-EPMC5248442 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature