Proteomics informed by transcriptomics for characterising active transposable elements and genome annotation in Aedes aegypti.

ABSTRACT:

Background

Aedes aegypti is a vector for the (re-)emerging human pathogens dengue, chikungunya, yellow fever and Zika viruses. Almost half of the Ae. aegypti genome is comprised of transposable elements (TEs). Transposons have been linked to diverse cellular processes, including the establishment of viral persistence in insects, an essential step in the transmission of vector-borne viruses. However, up until now it has not been possible to study the overall proteome derived from an organism's mobile genetic elements, partly due to the highly divergent nature of TEs. Furthermore, as for many non-model organisms, incomplete genome annotation has hampered proteomic studies on Ae. aegypti.

Results

We analysed the Ae. aegypti proteome using our new proteomics informed by transcri

SUBMITTER: Maringer K 

PROVIDER: S-EPMC5248466 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature