Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny.

ABSTRACT:

Background

Epidemiological studies suggest that hyponutrition during the fetal period increases the risk of mental disorders such as attention deficit hyperactivity disorder and autism-spectrum disorder, which has been experimentally supported using animal models. However, previous experimental hyponutrition or protein-restricted (PR) diets affected stages other than the fetal stage, such as formation of the egg before insemination, milk composition during lactation, and maternal nursing behavior.

Results

We conducted in vitro fertilization and embryo transfer in mice and allowed PR diet and folic acid-supplemented PR diet to affect only fetal environments. Comprehensive phenotyping of PR and control-diet progenies showed moderate differences in fear/anxiety-like, novelty-se

SUBMITTER: Furuse T 

PROVIDER: S-EPMC5248510 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature