Diastereomeric bactericidal effect of Ru(phenanthroline)₂ dipyridophenazine.

ABSTRACT: Metal susceptibility assays and spot plating were used to investigate the antimicrobial activity of enantiopure [Ru(phen)₂ dppz]²⁺ (phen =1,10-phenanthroline and dppz = dipyrido[3,2-a:2´,3´-c]phenazine) and [μ-bidppz(phen)₄ Ru₂ ]⁴⁺ (bidppz =11,11´-bis(dipyrido[3,2-a:2´,3´-c]phenazinyl)), on Gram-negative Escherichia coli and Gram-positive Bacillus subtilis as bacterial models. The minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined for both complexes: while [μ-bidppz(phen)₄ Ru₂ ]⁴⁺ only showed a bactericidal effect at the highest concentrations tested, the antimicrobial activity of [Ru(phen)₂ dppz]²⁺ against B.

SUBMITTER: Martensson AK 

PROVIDER: S-EPMC5248623 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature