Overall survival in renal cell carcinoma after introduction of targeted therapies: a Norwegian population-based study.

ABSTRACT:

Background

This population-wide retrospective, non-interventional registry study assessed changes in overall survival (OS) and factors influencing OS in Norwegian patients with renal cell carcinoma (RCC).

Methods

Two population-wide health registries were used to identify all RCC patients with (mRCC) or without metastases diagnosed before (2002-2005) and after (2006-2008 and 2009-2011) introduction of targeted therapies. Median OS was estimated using Kaplan-Meier method. Cox proportional hazards regression modeling was used to identify prognostic factors.

Results

Overall, 5,463 patients were diagnosed with RCC during 2002-2005 (n=1,898), 2006-2008 (n=1,631), and 2009-2011 (n=1,934); of these, 1,678 (31%) had mRCC. Patients diagnosed in 2009-2011 and 2006-2008 had sign

SUBMITTER: Beisland C 

PROVIDER: S-EPMC5248939 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature