FBLN4 as candidate gene associated with long-term and short-term survival with primary glioblastoma.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is the most common malignant and lethal type of primary central nervous system tumor in humans. In spite of its high lethality, a small percentage of patients have a relatively good prognosis, with median survival times of 36 months or longer. The identification of clinical subsets of GBM associated with distinct molecular genetic profiles has made it possible to design therapies tailored to treat individual patients.

Methods

We compared microarray data sets from long-term survivors (LTSs) and short-term survivors (STSs) to screen for prognostic biomarkers in GBM patients using the WebArrayDB platform. We focused on FBLN4, IGFBP-2, and CHI3L1, all members of a group of 10 of the most promising, differentially regu

SUBMITTER: Li F 

PROVIDER: S-EPMC5248947 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature