Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of ¹⁸F-FP-DTBZ in baboons.

ABSTRACT:

Introduction

¹⁸F-Fluoropropyl-(+)-dihydrotetrabenazine (¹⁸F-FP-(+)-DTBZ) is a vesicular monoamine transporter type 2 (VMAT2) radiotracer for positron emission tomography (PET) imaging to quantify human β-cell mass. Renal cortex and spleen have been suggested as reference regions, however, little is known about ¹⁸F-FP-(+)-DTBZ binding in these regions including the fraction of radiometabolite. We compared the kinetics of ¹⁸F-FP-(+)-DTBZ and its inactive enantiomer ¹⁸F-FP-(-)-DTBZ in baboons, estimated the non-displaceable binding (V_ND) of the tracers, and used ex vivo studies to measure radiometabolite fractions.

Methods

PET scans were conducted for up to 4h with (+) and (-) enantiomers. Displacement experiment

SUBMITTER: Naganawa M 

PROVIDER: S-EPMC5248981 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature