Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study.

ABSTRACT: Observational studies have shown that elevated systolic blood pressure (SBP) is associated with future onset of type 2 diabetes, but whether this association is causal is not known. We applied the Mendelian randomization framework to evaluate the causal hypothesis that elevated SBP increases risk for type 2 diabetes. We used 28 genetic variants associated with SBP and evaluated their impact on type 2 diabetes using a European-centric meta-analysis comprising 37,293 case and 125,686 control subjects. We found that elevation of SBP levels by 1 mmHg due to our genetic score was associated with a 2% increase in risk of type 2 diabetes (odds ratio 1.02, 95% CI 1.01-1.03, P = 9.05 × 10^-5). To limit confounding, we constructed a second score based on 13 variants exclusively associated

SUBMITTER: Aikens RC 

PROVIDER: S-EPMC5248987 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature