Genes of susceptibility to early neurodegenerative changes in the rat retina and brain: analysis by means of congenic strains.

ABSTRACT:

Background

There has been considerable interest in discovery of the genetic architecture of complex traits, particularly age-related neurodegenerative disorders. To predict disease risk and to understand its genetic basis in humans, it is necessary to study animal models. Our previous research on the accelerated-senescence OXYS strain has revealed two quantitative trait loci (QTLs) on rat chromosome 1 that are associated with early cataract and/or retinopathy as well as with behavioral abnormalities. Each locus was partially mapped within the introgressed segments in a certain congenic strain: WAG/OXYS-1.1 or WAG/OXYS-1.2. Retinal transcriptome profiling of 20-day-old congenic and OXYS rats by high-throughput RNA sequencing uncovered relevant candidate genes and pathways. Nonethele

SUBMITTER: Korbolina EE 

PROVIDER: S-EPMC5249004 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature