Differential expression of alternatively spliced transcripts related to energy metabolism in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. CRC molecular pathogenesis is heterogeneous and may be followed by mutations in oncogenes and tumor suppressor genes, chromosomal and microsatellite instability, alternative splicing alterations, hypermethylation of CpG islands, oxidative stress, impairment of different signaling pathways and energy metabolism. In the present work, we have studied the alterations of alternative splicing patterns of genes related to energy metabolism in CRC.

Results

Using CrossHub software, we analyzed The Cancer Genome Atlas (TCGA) RNA-Seq datasets derived from colon tumor and matched normal tissues. The expression of 1014 alternative mRNA isoforms involved in cell energy metabolism was examined. We foun

SUBMITTER: Snezhkina AV 

PROVIDER: S-EPMC5249009 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature