The gene-expression profile of renal medulla in ISIAH rats with inherited stress-induced arterial hypertension.

ABSTRACT:

Background

The changes in the renal function leading to a reduction of medullary blood flow can have a great impact on sodium and water homeostasis and on the long-term control of arterial blood pressure. The RNA-Seq approach was used for transcriptome profiling of the renal medulla from hypertensive ISIAH and normotensive WAG rats to uncover the genetic basis of the changes underlying the renal medulla function in the ISIAH rats being a model of the stress-sensitive arterial hypertension and to reveal the genes which possibly may contribute to the alterations in medullary blood flow.

Results

Multiple DEGs specifying the function of renal medulla in ISIAH rats were revealed. The group of DEGs described by Gene Ontology term 'oxidation reduction' was the most significantly en

SUBMITTER: Ryazanova MA 

PROVIDER: S-EPMC5249016 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature