Molecular determinants of the adrenal gland functioning related to stress-sensitive hypertension in ISIAH rats.

ABSTRACT:

Background

The adrenals are known as an important link in pathogenesis of arterial hypertensive disease. The study was directed to the adrenal transcriptome analysis in ISIAH rats with stress-sensitive arterial hypertension and predominant involvement in pathogenesis of the hypothalamic-pituitary-adrenal and sympathoadrenal systems.

Results

The RNA-Seq approach was used to perform the comparative adrenal transcriptome profiling in hypertensive ISIAH and normotensive WAG rats. Multiple differentially expressed genes (DEGs) related to different biological processes and metabolic pathways were detected. The discussion of the results helped to prioritize the several DEGs as the promising candidates for further studies of the genetic background underlying the stress-sensitive hyp

SUBMITTER: Fedoseeva LA 

PROVIDER: S-EPMC5249038 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature