Vasopressor Use for Severe Hypotension-A Multicentre Prospective Observational Study.

ABSTRACT:

Background

The optimal approach to titrate vasopressor therapy is unclear. Recent sepsis guidelines recommend a mean arterial pressure (MAP) target of 65 mmHg and higher for chronic hypertensive patients. As data emerge from clinical trials comparing blood pressure targets for vasopressor therapy, an accurate description of usual care is required to interpret study results. Our aim was to measure MAP values during vasopressor therapy in Canadian intensive care units (ICUs) and to compare these with stated practices and guidelines.

Method

In a multicenter prospective cohort study of critically ill adults with severe hypotension, we recorded MAP and vasopressor doses hourly. We investigated variability across patients and centres using multivariable regression models and Analy

SUBMITTER: Lamontagne F 

PROVIDER: S-EPMC5249049 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature