Review and Analysis of Publication Trends over Three Decades in Three High Impact Medicine Journals.

ABSTRACT:

Context

Over the past three decades, industry sponsored research expanded in the United States. Financial incentives can lead to potential conflicts of interest (COI) resulting in underreporting of negative study results.

Objective

We hypothesized that over the three decades, there would be an increase in: a) reporting of conflict of interest and source of funding; b) percentage of randomized control trials c) number of patients per study and d) industry funding.

Data sources and study selection

Original articles published in three calendar years (1988, 1998, and 2008) in The Lancet, New England Journal of Medicine and Journal of American Medical Association were collected.

Data extraction

Studies were reviewed and investigational design categorized as prospect

SUBMITTER: Ivanov A 

PROVIDER: S-EPMC5249065 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature