Regulatory Mechanisms Underlying the Expression of Prolactin Receptor in Chicken Granulosa Cells.

ABSTRACT: Prolactin (PRL) has both pro- and anti-gonadal roles in the regulation of avian ovarian functions through its interaction with the receptor (PRLR). However, neither the pattern of expression of PRLR nor its regulatory mechanisms during follicle development have been clearly defined. The objective of the present study was to investigate mechanisms of PRLR expression in chicken granulosa cells. Levels of PRLR transcript were highest in the stroma and walls of follicles < 2 mm in diameter and progressively declined with the maturation of follicles. In preovulatory follicles, PRLR was expressed at higher levels in granulosa than theca layers. FSH exerted the greatest stimulatory effect on PRLR and StAR expression in cultured granulosa cells of the 6-8 mm follicles but this effect declined as f

SUBMITTER: Hu S 

PROVIDER: S-EPMC5249103 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature