Decreased Functional Connectivity of Insular Cortex in Drug Naive First Episode Schizophrenia: In Relation to Symptom Severity.

ABSTRACT:

Background

This study was to examine the insular cortical functional connectivity in drug naïve patients with first episode schizophrenia and to explore the relationship between the connectivity and the severity of clinical symptoms.

Methods

Thirty-seven drug naïve patients with schizophrenia and 25 healthy controls were enrolled in this study. A seed-based approach was used to analyze the resting-state functional imaging data. Insular cortical connectivity maps were bilaterally extracted for group comparison and validated by voxel-based morphometry (VBM) analysis. Clinical symptoms were measured using the Positive and Negative Syndrome Scale (PANSS).

Results

There were significant reductions in the right insular cortical connectivity with the Heschl's gyrus, anterior

SUBMITTER: Pang L 

PROVIDER: S-EPMC5249106 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature