Sequence organization and insertion specificity of the novel chimeric ISHp609 transposable element of Helicobacter pylori.

ABSTRACT: Here we describe ISHp609 of Helicobacter pylori, a new member of the IS605 mobile element family that is novel and contains two genes whose functions are unknown, jhp960 and jhp961, in addition to homologs of two other H. pylori insertion sequence (IS) element genes, orfA, which encodes a putative serine recombinase-transposase, and orfB, whose homologs in other species are also often annotated as genes that encode transposases. The complete four-gene element was found in 10 to 40% of strains obtained from Africa, India, Europe, and the Americas but in only 1% of East Asian strains. Sequence comparison of 10 representative ISHp609 elements revealed higher levels of DNA sequence matches (99%) than those seen in normal chromosomal genes (88 to 98%) or in other IS elements (95 to 97% for IS60

SUBMITTER: Kersulyte D 

PROVIDER: S-EPMC524915 | biostudies-literature | 2004 Nov

REPOSITORIES: biostudies-literature