Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety.

ABSTRACT:

Objectives

To systematically review the literature comparing the efficacy and safety of dexmedetomidine and midazolam when used for procedural sedation.

Materials and methods

We searched MEDLINE, EMBASE and COCHRANE for clinical trials comparing dexmedetomidine and midazolam for procedural sedation up to June 20, 2016. Inclusion criteria: clinical trial, human subjects, adult subjects (≥18 years), article written in English, German, French or Dutch, use of study medication for conscious sedation and at least one group receiving dexmedetomidine and one group receiving midazolam. Exclusion criteria: patients in intensive care, pediatric subjects and per protocol use of additional sedative medication other than rescue medication. Outcome measures for efficacy comparison were pa

SUBMITTER: Barends CR 

PROVIDER: S-EPMC5249234 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature