Bi-directional analysis between fatty liver and cardiovascular disease risk factors.

ABSTRACT:

Background & aims

The relations of non-alcoholic fatty liver disease to cardiovascular disease (CVD) risk factors are not fully understood. The objective of our study is to explore the bi-directional relationships of fatty liver to CVD risk factors.

Methods

We prospectively evaluated whether liver fat predicted the development of CVD risk factors and whether CVD risk factors predicted new onset fatty liver during 6years of follow-up in middle- to older-aged Framingham Heart Study participants. We estimated liver fat using multi-detector computed tomography.

Results

We included 1051 participants (mean age 45±6years, 46% women). The prevalence of fatty liver was 18% at baseline. In participants without fatty liver at baseline, 101 participants developed incident fatty l

SUBMITTER: Ma J 

PROVIDER: S-EPMC5250546 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature