Hypertension-Linked Pathophysiological Alterations in the Gut.

ABSTRACT:

Rationale

Sympathetic nervous system control of inflammation plays a central role in hypertension. The gut receives significant sympathetic innervation, is densely populated with a diverse microbial ecosystem, and contains immune cells that greatly impact overall inflammatory homeostasis. Despite this uniqueness, little is known about the involvement of the gut in hypertension.

Objective

Test the hypothesis that increased sympathetic drive to the gut is associated with increased gut wall permeability, increased inflammatory status, and microbial dysbiosis and that these gut pathological changes are linked to hypertension.

Methods and results

Gut epithelial integrity and wall pathology were examined in spontaneously hypertensive rat and chronic angiotensin II infusion

SUBMITTER: Santisteban MM 

PROVIDER: S-EPMC5250568 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature