Dual specificity phosphatase 15 regulates Erk activation in Schwann cells.

ABSTRACT: Schwann cells and oligodendrocytes are the myelinating cells of the peripheral and central nervous system, respectively. Despite having different myelin components and different transcription factors driving their terminal differentiation there are shared molecular mechanisms between the two. Sox10 is one common transcription factor required for several steps in development of myelinating glia. However, other factors are divergent as Schwann cells need the transcription factor early growth response 2/Krox20 and oligodendrocytes require Myrf. Likewise, some signaling pathways, like the Erk1/2 kinases, are necessary in both cell types for proper myelination. Nonetheless, the molecular mechanisms that control this shared signaling pathway in myelinating cells remain only partially characteriz

SUBMITTER: Rodriguez-Molina JF 

PROVIDER: S-EPMC5250571 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature