TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection.

ABSTRACT: Calcium signaling in phagocytes is essential for cellular activation, migration, and the potential resolution of infection or inflammation. The generation of reactive oxygen species (ROS) via activation of NADPH (nicotinamide adenine dinucleotide phosphate)-oxidase activity in macrophages has been linked to altered intracellular calcium concentrations. Because of its role as an oxidative stress sensor in phagocytes, we investigated the function of the cation channel transient receptor potential melastatin 2 (TRPM2) in macrophages during oxidative stress responses induced by Helicobacter pylori infection. We show that Trpm2^-/^- mice, when chronically infected with H. pylori, exhibit increased gastric inflammation and decreased bacterial colonization compared with wild-t

SUBMITTER: Beceiro S 

PROVIDER: S-EPMC5250617 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature