S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands.

ABSTRACT:

Background

Sigma (σ) receptors are accepted as a particular receptor class consisting of two subtypes: sigma-1 (σ₁) and sigma-2 (σ₂). The two receptor subtypes have specific drug actions, pharmacological profiles and molecular characteristics. The σ₂ receptor is overexpressed in several tumor cell lines, and its ligands are currently under investigation for their role in tumor diagnosis and treatment. The σ₂ receptor structure has not been disclosed, and researchers rely on σ₂ receptor radioligand binding assay to understand the receptor's pharmacological behavior and design new lead compounds.

Description

Here we present the sigma-2 Receptor Selective Ligands Database (S2RSLDB) a manually curated database of the σ₂

SUBMITTER: Nastasi G 

PROVIDER: S-EPMC5250622 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature