Rapid PD-L1 detection in tumors with PET using a highly specific peptide.

ABSTRACT: Molecular imaging can report on the status of the tumor immune microenvironment and guide immunotherapeutic strategies to enhance the efficacy of immune modulation therapies. Imaging agents that can rapidly report on targets of immunomodulatory therapies are few. The programmed death ligand 1 (PD-L1) is an immune checkpoint protein over-expressed in several cancers and contributes to tumor immune suppression. Tumor PD-L1 expression is indicative of tumor response to PD-1 and PD-L1 targeted therapies. Herein, we report a highly specific peptide-based positron emission tomography (PET) imaging agent for PD-L1. We assessed the binding modes of the peptide WL12 to PD-L1 by docking studies, developed a copper-64 labeled WL12 ([⁶⁴Cu]WL12), and performed its evaluation in vitro, and in

SUBMITTER: Chatterjee S 

PROVIDER: S-EPMC5253331 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature