Luteolin improves cardiac dysfunction in heart failure rats by regulating sarcoplasmic reticulum Ca²⁺-ATPase 2a.

ABSTRACT: We previously found that luteolin (Lut) appeared to improve the contractility of cardiomyocytes during ischemia/reperfusion in rats. The enhancement was associated with the alteration in sarcoplasmic reticulum Ca²⁺-ATPase 2a (SERCA2a). This finding prompted us to consider if the mechanism worked in heart failure (HF). We studied the regulation of SERCA2a by Lut in failing cardiomyocytes and intact heart of rats. Improvement of contractility and the mechanisms centered on SERCA2a were studied in isolated cardiomyocytes and intact heart. We found that Lut significantly improved contractility and Ca²⁺ transients, ameliorated expression, activity and stability of SERCA2a and upregulated expression of small ubiquitin-related modifier (SUMO) 1, which is a newfound SERCA2a r

SUBMITTER: Hu W 

PROVIDER: S-EPMC5253630 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature