Novel mutations within the embB gene in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis.

ABSTRACT: Genetic analysis of the embB gene revealed mutations in 17 (68%) of 25 ethambutol (EMB) resistant isolates (M306I, M306V, M306L, Q497R) but also in 4 (20%) of 20 EMB-susceptible isolates of Mycobacterium tuberculosis, namely, an ATG-->ATM substitution resulting in M306I, G406N, and the novel alterations M423I and A659T.

SUBMITTER: Lee AS 

PROVIDER: S-EPMC525425 | biostudies-literature | 2004 Nov

REPOSITORIES: biostudies-literature