Circulating CXCR5⁺CXCR3⁺PD-1^lo Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth.

ABSTRACT: HIV-1-specific broadly neutralizing antibodies (bnAbs) typically develop in individuals with continuous high-level viral replication and increased immune activation, conditions that cannot be reproduced during prophylactic immunization. Understanding mechanisms supporting bnAb development in the absence of high-level viremia may be important for designing bnAb-inducing immunogens. Here, we show that the breadth of neutralizing antibody responses in HIV-1 controllers was associated with a relative enrichment of circulating CXCR5⁺CXCR3⁺PD-1^lo CD4⁺ T cells. These CXCR3⁺PD-1^lo Tfh-like cells were preferentially induced in vitro by functionally superior dendritic cells from controller neutralizers, and able to secrete IL-21 and s

SUBMITTER: Martin-Gayo E 

PROVIDER: S-EPMC5256133 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature