High-angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults.

ABSTRACT:

Introduction

Many neurologic and psychiatric disorders are thought to be due to, or result in, developmental errors in neuronal cerebellar connectivity. In this connectivity analysis, we studied the developmental time-course of cerebellar peduncle pathways in pediatric and young adult subjects.

Methods

A cohort of 80 subjects, newborns to young adults, was studied on a 3T MR system with 30 diffusion-weighted measurements with high-angular resolution diffusion imaging (HARDI) tractography.

Results

Qualitative and quantitative results were analyzed for age-based variation. In subjects of all ages, the superior cerebellar peduncle pathway (SCP) and two distinct subpathways of the middle cerebellar peduncle (MCP), as described in previous ex vivo studies, were iden

SUBMITTER: Re TJ 

PROVIDER: S-EPMC5256176 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature