Increased thalamic centrality and putamen-thalamic connectivity in patients with parkinsonian resting tremor.

ABSTRACT:

Introduction

Evidence has indicated a strong association between hyperactivity in the cerebello-thalamo-motor cortical loop and resting tremor in Parkinson's disease (PD). Within this loop, the thalamus serves as a central hub based on its structural centrality in the generation of resting tremor. To study whether this thalamic abnormality leads to an alteration at the whole-brain level, our study investigated the role of the thalamus in patients with parkinsonian resting tremor in a large-scale brain network context.

Methods

Forty-one patients with PD (22 with resting tremor, TP and 19 without resting tremor, NTP) and 45 healthy controls (HC) were included in this resting-state functional MRI study. Graph theory-based network analysis was performed to examine the centrality

SUBMITTER: Gu Q 

PROVIDER: S-EPMC5256184 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature