A novel method for multiple alignment of sequences with repeated and shuffled elements.

ABSTRACT: We describe ABA (A-Bruijn alignment), a new method for multiple alignment of biological sequences. The major difference between ABA and existing multiple alignment methods is that ABA represents an alignment as a directed graph, possibly containing cycles. This representation provides more flexibility than does a traditional alignment matrix or the recently introduced partial order alignment (POA) graph by allowing a larger class of evolutionary relationships between the aligned sequences. Our graph representation is particularly well-suited to the alignment of protein sequences with shuffled and/or repeated domain structure, and allows one to construct multiple alignments of proteins containing (1) domains that are not present in all proteins, (2) domains that are present in different ord

SUBMITTER: Raphael B 

PROVIDER: S-EPMC525693 | biostudies-literature | 2004 Nov

REPOSITORIES: biostudies-literature