Stratification of endometrioid endometrial cancer patients into risk levels using somatic mutations.

ABSTRACT:

Objective

Patients with endometrioid endometrial cancer are stratified as high risk and low risk for extrauterine disease by surgical staging. Since patients with low-grade, minimally invasive disease do not benefit from comprehensive staging, pre-surgery stratification into a risk category may prevent unnecessary surgical staging in low risk patients. Our objective was to develop a predictive model to identify risk levels using somatic mutations that could be used preoperatively.

Methods

We classified endometrioid endometrial cancer patients in The Cancer Genome Atlas (TCGA) dataset into high risk and low risk categories: high risk patients presented with stage II, III or IV disease or stage I with high-intermediate risk features, whereas low risk patients consisted of the

SUBMITTER: Dai D 

PROVIDER: S-EPMC5257080 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature