The Impact of Multipollutant Clusters on the Association Between Fine Particulate Air Pollution and Microvascular Function.

ABSTRACT:

Background

Prior studies including the Framingham Heart Study have suggested associations between single components of air pollution and vascular function; however, underlying mixtures of air pollution may have distinct associations with vascular function.

Methods

We used a k-means approach to construct five distinct pollution mixtures from elemental analyses of particle filters, air pollution monitoring data, and meteorology. Exposure was modeled as an interaction between fine particle mass (PM2.5), and concurrent pollution cluster. Outcome variables were two measures of microvascular function in the fingertip in the Framingham Offspring and Third Generation cohorts from 2003 to 2008.

Results

In 1,720 participants, associations between PM2.5 and baseline pulse amplit

SUBMITTER: Ljungman PL 

PROVIDER: S-EPMC5257194 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature