Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy.

ABSTRACT:

Background

Major trauma is a leading cause of morbidity and mortality worldwide with hemorrhage accounting for 40% of deaths. Acute traumatic coagulopathy exacerbates bleeding, but controversy remains over the degree to which inhibition of procoagulant pathways (anticoagulation), fibrinogen loss, and fibrinolysis drive the pathologic process. Through a combination of experimental study in a murine model of trauma hemorrhage and human observation, the authors' objective was to determine the predominant pathophysiology of acute traumatic coagulopathy.

Methods

First, a prospective cohort study of 300 trauma patients admitted to a single level 1 trauma center with blood samples collected on arrival was performed. Second, a murine model of acute traumatic coagulopathy with suppre

SUBMITTER: Davenport RA 

PROVIDER: S-EPMC5257267 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature