Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults.

ABSTRACT:

Importance

Emotional and behavioral symptoms in cognitively normal older people may be direct manifestations of Alzheimer disease (AD) pathophysiology at the preclinical stage, prior to the onset of mild cognitive impairment. Loneliness is a perceived state of social and emotional isolation that has been associated with cognitive and functional decline and an increased risk of incident AD dementia. We hypothesized that loneliness might occur in association with elevated cortical amyloid burden, an in vivo research biomarker of AD.

Objective

To determine whether cortical amyloid burden is associated with greater loneliness in cognitively normal older adults.

Design, setting, and participants

Cross-sectional analyses using data from the Harvard Aging Brain Study of 79 c

SUBMITTER: Donovan NJ 

PROVIDER: S-EPMC5257284 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature