Lymphadenectomy for Adrenocortical Carcinoma: Is There a Therapeutic Benefit?

ABSTRACT:

Background

Lymph node metastasis is an established predictor of poor outcome for adrenocortical carcinoma (ACC); however, routine lymphadenectomy during surgical resection of ACC is not widely performed and its therapeutic role remains unclear.

Methods

Patients undergoing margin-negative resection for localized ACC were identified from a multi-institutional database. Patients were stratified into 2 groups based on the surgeon's effort or not to perform a lymphadenectomy as documented in the operative note. Clinical, pathologic, and outcome data were compared between the 2 groups.

Results

Of 120 patients who met inclusion criteria from 1993 to 2014, 32 (27 %) underwent lymphadenectomy. Factors associated with lymphadenectomy were tumor size (12 vs. 9.5 cm; p = .007), p

SUBMITTER: Gerry JM 

PROVIDER: S-EPMC5257294 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature