Impact of industry collaboration on randomised controlled trials in oncology.

ABSTRACT:

Background

Industry funders can simply provide money or collaborate in trial design, analysis or reporting of clinical trials. Our aim was to assess the impact of industry collaboration on trial methodology and results of randomised controlled trials (RCT).

Methods

We searched PubMed for oncology RCTs published May 2013 to December 2015 in peer-reviewed journals with impact factor > 5 requiring reporting of funder role. Two authors extracted methodologic (primary end-point; blinding of the patient, clinician and outcomes assessor; and analysis) and outcome data. We used descriptive statistics and two-sided Fisher exact tests to compare characteristics of trials with collaboration, with industry funding only, and without industry funding.

Results

We included 224 trials

SUBMITTER: Linker A 

PROVIDER: S-EPMC5258680 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature