Functional Characterization of Rhoptry Kinome in the Virulent Toxoplasma gondii RH Strain.

ABSTRACT: Toxoplasma gondii is an obligatory intracellular apicomplexan protozoan which can infect any warm-blooded animal and causes severe diseases in immunocompromised individuals or infants infected in utero. The survival and success of this parasite require that it colonizes the host cell, avoids host immune defenses, replicates within an appropriate niche, and exits the infected host cell to spread to neighboring non-infected cells. All of these processes depend on the parasite ability to synthesis and export secreted proteins. Amongst the secreted proteins, rhoptry organelle proteins (ROPs) are essential for the parasite invasion and host cell manipulation. Even though the functions of most ROPs have been elucidated in the less virulent T. gondii (type II), the roles of ROPs in

SUBMITTER: Wang JL 

PROVIDER: S-EPMC5258691 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature