Modulation of Human Peripheral Blood Mononuclear Cell Signaling by Medicinal Cannabinoids.

ABSTRACT: Medical marijuana is increasingly prescribed as an analgesic for a growing number of indications, amongst which terminal cancer and multiple sclerosis. However, the mechanistic aspects and properties of cannabis remain remarkably poorly characterized. In this study we aimed to investigate the immune-cell modulatory properties of medical cannabis. Healthy volunteers were asked to ingest medical cannabis, and kinome profiling was used to generate comprehensive descriptions of the cannabis challenge on inflammatory signal transduction in the peripheral blood of these volunteers. Results were related to both short term and long term effects in patients experimentally treated with a medical marijuana preparation for suffering from abdominal pain as a result of chronic pancreatitis or other caus

SUBMITTER: Utomo WK 

PROVIDER: S-EPMC5258717 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature