Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor.

ABSTRACT: Several studies have demonstrated the expression of odorant receptors (OR) in various human tissues and their involvement in different physiological and pathophysiological processes. However, the functional role of ORs in the human heart is still unclear. Here, we firstly report the functional characterization of an OR in the human heart. Initial next-generation sequencing analysis revealed the OR expression pattern in the adult and fetal human heart and identified the fatty acid-sensing OR51E1 as the most highly expressed OR in both cardiac development stages. An extensive characterization of the OR51E1 ligand profile by luciferase reporter gene activation assay identified 2-ethylhexanoic acid as a receptor antagonist and various structurally related fatty acids as novel OR51E1 ligands, s

SUBMITTER: Jovancevic N 

PROVIDER: S-EPMC5258789 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature