Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer.

ABSTRACT:

Background

The genetic and clinical heterogeneity of breast cancer makes the identification of effective therapies challenging. We designed I-SPY 2, a phase 2, multicenter, adaptively randomized trial to screen multiple experimental regimens in combination with standard neoadjuvant chemotherapy for breast cancer. The goal is to match experimental regimens with responding cancer subtypes. We report results for veliparib, a poly(ADP-ribose) polymerase (PARP) inhibitor, combined with carboplatin.

Methods

In this ongoing trial, women are eligible for participation if they have stage II or III breast cancer with a tumor 2.5 cm or larger in diameter; cancers are categorized into eight biomarker subtypes on the basis of status with regard to human epidermal growth factor receptor 2

SUBMITTER: Rugo HS 

PROVIDER: S-EPMC5259561 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature