Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium.

ABSTRACT: The Ebola crisis occurred in West-Africa highlights the urgency for its clinical treatments. Currently, no Food and Drug Administration (FDA)-approved therapeutics are available. Several FDA-approved drugs, including selective estrogen receptor modulators (SERMs), possess selective anti-Ebola activities. However, the inhibitory mechanisms of these drugs remain elusive. By analyzing the structures of SERMs and their incidental biological activity (cholesterol accumulation), we hypothesized that this incidental biological activity induced by SERMs could be a plausible mechanism as to their inhibitory effects on Ebola infection. Herein, we demonstrated that the same dosages of SERMs which induced cholesterol accumulation also inhibited Ebola infection. SERMs reduced the cellular sphingosine a

SUBMITTER: Fan H 

PROVIDER: S-EPMC5259750 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature