Ligand binding pocket of a novel Allatostatin receptor type C of stick insect, Carausius morosus.

ABSTRACT: Allatostatins (AST) are neuropeptides with variable function ranging from regulation of developmental processes to the feeding behavior in insects. They exert their effects by binding to cognate GPCRs, called Allatostatin receptors (AlstR), which emerge as promising targets for pesticide design. However, AlstRs are rarely studied. This study is the first reported structural study on AlstR-AST interaction. In this work, the first C type AlstR from the stick insect Carausius morosus (CamAlstR-C) was identified and its interaction with type C AST peptide was shown to be physically consistent with the experimental results. The proposed structure of CamAlstR-C revealed a conserved motif within the third extracellular loop, which, together with the N-terminus is essential for ligand binding. In

SUBMITTER: Duan Sahbaz B 

PROVIDER: S-EPMC5259779 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature