Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis.

ABSTRACT: The small heterodimer partner (SHP) is an orphan nuclear receptor that lacks the DNA binding domain while conserves a putative ligand-binding site, thought that endogenous ligands for this receptor are unknown. Previous studies have determined that SHP activation protects against development of liver fibrosis a process driven by trans-differentiation and activation of hepatic stellate cells (HSCs), a miofibroblast like cell type, involved in extracellular matrix (ECM) deposition. To dissect signals involved in this activity we generated SHP-overexpressing human and rat HSCs. Forced expression of SHP in HSC-T6 altered the expression of 574 genes. By pathway and functional enrichment analyses we detected a cluster of 46 differentially expressed genes involved in HSCs trans-differentiation. U

SUBMITTER: Cipriani S 

PROVIDER: S-EPMC5259793 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature