Identification of recurrent combinatorial patterns of chromatin modifications at promoters across various tissue types.

ABSTRACT:

Background

Identification and analysis of recurrent combinatorial patterns of multiple chromatin modifications provide invaluable information for understanding epigenetic regulations. Furthermore, as more data becomes available, it is computationally expensive and unnecessary to study combinatorial patterns of all modifications.

Methods

A novel framework is proposed to investigate recurrent combinatorial patterns of a subset of quantitatively selected chromatin modifications. The framework is based on heirarchical clustering and selects subsets of chromatin modifications that form distinct recurrent patterns at regulatory regions. The identified recurrent combinatorial patterns can be further utilized to discover novel regulatory regions. Data is in the form of genome wide m

SUBMITTER: Meng N 

PROVIDER: S-EPMC5259941 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature