A network-based pathway-expanding approach for pathway analysis.

ABSTRACT:

Background

Pathway analysis combining multiple types of high-throughput data, such as genomics and proteomics, has become the first choice to gain insights into the pathogenesis of complex diseases. Currently, several pathway analysis methods have been developed to study complex diseases. However, these methods did not take into account the interaction between internal and external genes of the pathway and between pathways. Hence, these approaches still face some challenges. Here, we propose a network-based pathway-expanding approach that takes the topological structures of biological networks into account.

Results

First, two weighted gene-gene interaction networks (tumor and normal) are constructed integrating protein-protein interaction(PPI) information, gene expression da

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC5259956 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature